Pharmacokinetic/Pharmacodynamic Modelling of Allopurinol, its Active Metabolite Oxypurinol, and Biomarkers Hypoxanthine, Xanthine and Uric Acid in Hypoxic-Ischemic Encephalopathy Neonates

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Authors: Wan-Yu Chu, Kim V Annink, A Laura Nijstad, Christian A Maiwald, Michael Schroth, Loubna El Bakkali, Frank van Bel, Manon J N L Benders, Mirjam M van Weissenbruch, Anja Hagen, Axel R Franz, Thomas P C Dorlo, Karel Allegaert, Alwin D R Huitema; ALBINO Study Group

Journal title: Clinical Pharmakokinetics

Journal publisher: Adis International Ltd.

Published year: 2022

Published pages: 321-333

DOI identifier: 10.1007/s40262-021-01068-0

ISSN: 0312-5963