Reproducible force-distance curves

Reproducible force-distance curves that can be correlated with super-resolution images In this task we use the approaches developed in task 3.2 to enhance our understanding of the mechanical and structural properties of chromosomes by combining micro-mechanical manipulation with super-resolution imaging. The VU, UCPH and UCL will investigate chromosomes with known defects, such as chromosome fragility. The experiments will yield information in the differences between the structural and mechanical properties of healthy and diseased chromosomes. Our aim is to reveal correlations between protein structures and the mechanical response of chromosomes to elucidate the nature/origin of chromosome architecture as well as defects.