Tumor models established

We will setup two melanoma mouse models the transplantable B16F1 in C57Bl6N mice and spontaneous HGFCDK4 models for which the phenotype and transcriptomic profile of antitumor T cells have been characterised Tumor cells will be injected subcutaneously and stem cell memory potent antitumor T cells or effector memory dysfunctional antitumor T cells Pmel1 transgenic T cells will be injected intravenously 7days post tumor take