One genetic switch for self-destroying the endogenous DNA upon exposure to a chemical inducer.

The aim here is to have the choice of destroying altogether the genetic material of E coli and P putida while preserving the whole of the biochemical networks For this the genes ungdut will be deleted and replaced by a tightly regulated ung dut bicistronic operon inducible upon exposure of cells to an external effector eg 3 methylbenzoate While the lack of ungdut will make many Ts of the genome being replaced by U residues their abrupt expression will cleave the chromosome at multiple sites thus converting the cells in a sort of chemical vesicle These will be excellent vessels to develop NTN reactions and as recipients of heavily mutated and edited artificial chromosomes