Non-lipid vesicles:physical samples, synthesis protocols, characterization database

Vesicular nanoparticles comprising non-lipidic or lipids/non-lipids components will provide additional avenues for construction of vesicle platforms. In particular, inclusion in the vesicle frameworks of amphiphilic conjugated polymers, dendrimers (d) and hydrophobically-coated nanoparticles, will provide means for tuning of desired properties, particularly vesicle size, shape, and rigidity of the molecular scaffolding. Specific non-lipid vesicles which will be explored include polymerized lipid/polydiacetylene vesicles comprising lipids and polydiacetylene, and vesicles built from bolaamphiphiles, containing two hydrophilic head groups linked at each end through a hydrophobic alkylchain, exhibiting high thermodynamic stability in physiological samples.