Report on characterization of micro-sensors to biological sensing with frequency

During this task, microfabrication processes, advanced silicon micromachining and packaging processes will be developed. Prototypes of the array of acoustic wave micro-sensors and the measurement cell will be delivered, followed by exhaustive characterization. Using impedance and network analysers, the complex electromechanical response of the array will be measured in the frequency range of interest. Cross-sensitivity (interferences) between micro-sensor situated closely in the array will also be studied. Microsensors operation in biological sensing will be tested during the binding of a model system consisting of DNA molecules followed by liposomes; testing will be performed using P3’s already commercially available instrumentation. This testing will provide an acoustic database of dissipation measurements versus frequency for DNAs and liposomes of various features. Results will be used to decide on the most appropriate operation frequency for maximum enhancement of the dissipation response.