Periodic Reporting for period 3 - Mito-recombine (Homologous recombination and its application in manipulating animal mitochondrial DNA)

Mitochondria, the key providers of cellular energy, are semi-autonomous organelles that house their own genome (mtDNA). Despite carrying a small number of genes, mtDNA has a big impact on health and disease. In humans, over 350 mtDNA mutations have been linked to a spectrum of...