Periodic Reporting for period 5 - CD40-INN (CD40 goes innate: defining and targeting CD40 signaling intermediates in the macrophage to treat atherosclerosis)

Atherosclerosis, the underlying cause of the majority of cardiovascular diseases (CVD), is a lipid driven, inflammatory disease of the large arteries. Although the development of lipid lowering drugs, in particular HMG-CoA reductase inhibitors (statins), has helped to lower...