Periodic Reporting for period 1 - CannaPreg (Development of pregnenolone derivatives as allosteric inhibitors of CB1 cannabinoid receptors for thetreatment of schizophrenia and psychotic syndromes)

Excessive activation of the cannabinoid type-1 receptor (CB1) in the brain by synthetic, endogenous or plant-derived(cannabis sativa) cannabinoids can lead to pathological states, which could be ameliorated by blocking receptor signalling.However, due to the large number of...