Periodic Reporting for period 4 - ThymusTolerance (Delineation of molecular mechanisms underlying the establishment and breakdown of immunological tolerance in the thymus)

Medullary thymus epithelial cells (mTECs) play a pivotal role in pruning self-reactive thymocytes from the T cell repertoire, thanks to their capacity to promiscuously express and present almost all self-antigens, including thousands of tissue-specific antigen (TSA) genes...