Periodic Reporting for period 2 - Merlin (MEtabolic Cell Reprogramming for the Recovery of Lost INsulin-Producing Cells)

We aim at fostering the regeneration of insulin-producing beta-cells in the diabetic pancreas, by promoting the reprogramming of other islet cell-types, so-called “non-beta” cells. We previously developed transgenic mice where we elicit total (>99%) or graded controlled...