Using antagonistic pleiotropy to design a chemotherapy-induced evolutionary trap to target drug resistance in cancer

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Authors: Kevin H. Lin, Justine C. Rutter, Abigail Xie, Bryann Pardieu, Emily T. Winn, Reinaldo Dal Bello, Antoine Forget, Raphael Itzykson, Yeong-Ran Ahn, Ziwei Dai, Raiyan T. Sobhan, Grace R. Anderson, Katherine R. Singleton, Amy E. Decker, Peter S. Winter, Jason W. Locasale, Lorin Crawford, Alexandre Puissant, Kris C. Wood

Journal title: Nature Genetics

Journal number: 52/4

Journal publisher: Nature Publishing Group

Published year: 2020

Published pages: 408-417

DOI identifier: 10.1038/s41588-020-0590-9

ISSN: 1061-4036