Tautomer-Specific Deacylation and Ω-Loop Flexibility Explain the Carbapenem-Hydrolyzing Broad-Spectrum Activity of the KPC-2 β-Lactamase

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Authors: Catherine L. Tooke; Philip Hinchliffe; Michael Beer; Kirill Zinovjev; Charlotte K. Colenso; Christopher J. Schofield; Adrian J. Mulholland; James Spencer

Journal title: Journal of the American Chemical Society

Journal number: 145

Journal publisher: American Chemical Society

Published year: 2023

Published pages: 7166-7180

DOI identifier: 10.1021/jacs.2c12123

ISSN: 0002-7863