Periodic Reporting for period 4 - EVI1inCancer (Overcoming the epigenetic and therapeutic barrier of EVI1-overexpressing cancers)

EVI1 is a proto-oncogene frequently activated in high-risk leukemias and other cancers (e.g. high-grade ovarian cancer, breast cancer), however the cause of EVI1 transcriptional activation and the mechanism of EVI1-induced transformation are poorly understood. At present...