Periodic Reporting for period 3 - SELFOR (How our adaptive immune system separates “self” from “foreign” – a physicochemical study of binding in cell contacts)

The main goal of this project is to illuminate the problem of antigen discrimination by developing a physicochemical understanding of the interaction between T-cell receptors (TCRs) and peptide-loaded major histocompatibility complexes (pMHCs), and how this differs for pMHC...