A NAC domain mutation (E83Q) unlocks the pathogenicity of human alpha-synuclein and recapitulates its pathological diversity

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Authors: Senthil T. Kumar; Anne-Laure Mahul-Mellier; Ramanath Narayana Hegde; Gwladys Rivière; Rani Moons; Alain Ibáñez de Opakua; Pedro Magalhães; Iman Rostami; Sonia Donzelli; Frank Sobott; Markus Zweckstetter; Hilal A. Lashuel

Journal title: Science Advances

Journal number: 1

Journal publisher: American Association for the Advancement of Science

Published year: 2022

DOI identifier: 10.1126/sciadv.abn0044

ISSN: 2375-2548