Periodic Reporting for period 4 - SPOCkS MS (Sampling Protein cOmplex Conformational Space with native top down Mass Spectrometry)

The main question to be addressed by SPOCk’S MS is how protein complex conformation adapts to local changes, such as processing of polyproteins, protein phosphorylation or conversion of substrates. While labelling strategies combined with mass spectrometry (MS), such as...