Periodic Reporting for period 1 - DUPDOWN (Deacetylase inhibitors for autism spectrum disorders: an integrated preclinical validation pipeline in brain organoids and in vivo models)

The aim of this proposal was to test the efficacy of compounds that modify gene expression (histone deacetylase inhibitors) as potential treatments for Autism Spectrum Disorders (ASD). ASD comprise a very diverse group of clinical phenotypes caused by alterations in human DNA...