Periodic Reporting for period 4 - DUT-signal (dUTPase Signalling: from Phage to Eukaryotes)

Preserving DNA integrity is of vital importance for all organisms. Genomes of all free-living organisms and many viruses encode the enzyme dUTPase (dUTP pyrophosphatase; DUT; EC 3.6.1.23), which cleaves dUTP into dUMP and pyrophosphate. Since most DNA polymerases cannot...