Periodic Reporting for period 1 - RE-STORE (Pharmacological restoration of selective autophagy for the treatment of skeletal disorders)

The ERC Starting grant BONEPHAGY allowed Dr. Settembre’s lab to identify and characterize an ER-to-lysosome procollagen trafficking route that is essential for collagen secretion. This process is mediated by autophagy of the endoplasmic reticulum (ER-phagy), via its receptor...