Periodic Reporting for period 3 - TeloRNAging (The role of damage-induced non coding RNA in the control of DNA damage response activation at telomeres in aging)

This project aims to elucidate the role of telomeric non-coding RNA (tncRNA), which are transcribed following telomere dysfunction, in the activation of the DNA damage response (DDR). By exploiting our unprecedented ability to inhibit DDR selectively at telomeres by inhibit...