Periodic Reporting for period 2 - CancerEpiTopology (Elucidating the mechanisms, heterogeneity and role of epigenetic topological alterations in cancer)

Cancer genomics has revolutionized cancer research by systematic mapping of oncogenic genetic alterations of genes, yet oncogenic epigenetic alterations of regulatory elements away from genes remain elusive. One of the key epigenetic mechanism is methylation of DNA, which is...