Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity

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Authors: Daniel Rehling, Si Min Zhang, Ann-Sofie Jemth, Tobias Koolmeister, Adam Throup, Olov Wallner, Emma Scaletti, Takaya Moriyama, Rina Nishii, Jonathan Davies, Matthieu Desroses, Sean G. Rudd, Martin Scobie, Evert Homan, Ulrika Warpman Berglund, Jun J. Yang, Thomas Helleday, Pål Stenmark

Journal title: Journal of Biological Chemistry

Journal number: 296

Journal publisher: American Society for Biochemistry and Molecular Biology Inc.

Published year: 2021

Published pages: 100568

DOI identifier: 10.1016/j.jbc.2021.100568

ISSN: 0021-9258