Periodic Reporting for period 1 - DOIIF (Development of small molecule OGG1 Inhibitor and proof of concept in bleomycin-induced disease model of Inflammation and pulmonary Fibrosis)

OGG1 enzyme has a major role in DNA repair in conditions of oxidative stress and also in regulation of gene transcription involved in immune responses and development of fibrotic scars in tissue. Genetic knock-out of OGG1 or treatment with OGG1 inhibitors have shown to protect...