Periodic Reporting for period 5 - PhaseAge (The chemistry and physics of RNP granules: how they form, age and cause disease)

RBPs are a highly abundant class of proteins that associate with RNAs to form ribonucleoprotein particles (RNPs). Recent studies suggest that defective RNP granules and alterations in RNA metabolism are linked to neurodegenerative diseases, ALS and FTD. However, defective RNP...