Periodic Reporting for period 3 - GENSURGE (Designer recombinases for efficient and safe genome surgery)

Homing endonucleases, zinc finger nucleases (ZFN), Transcription activator-like effector nucleases (TALEN) and most recently the Clustered regularly interspaced short palindromic repeats (CRISPR) Cas-system are very powerful tools to engineer the genome in living cells...