Specificity Effects of Amino Acid Substitutions in Promiscuous Hydrolases: Context-Dependence of Catalytic Residue Contributions to Local Fitness Landscapes in Nearby Sequence Space

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Authors: Christopher D. Bayer, Bert van Loo, Florian Hollfelder

Journal title: ChemBioChem

Journal number: 18/11

Journal publisher: John Wiley & Sons Ltd.

Published year: 2017

Published pages: 1001-1015

DOI identifier: 10.1002/cbic.201600657

ISSN: 1439-4227