Periodic Reporting for period 3 - ONCOFUM (Integrating the tissue-specificity and chronology of hereditary renal cancer predisposition)

During the first period of ONCOFUM, we studied the consequences of Fh1 loss in mouse and newly generated human models. We found that the loss of FH in kidney tubules promotes Atf4 translation and activates the integrated stress response in murine models, both in vitro and in...