Periodic Reporting for period 1 - TARGET_SYNAPTIC_TAU (Targeting Tau-induced cognitive decline with antisense oligonucleotides to synaptogyrin-3)

Tauopathies (that include Alzheimer’s disease) are characterized by defects in the microtubule-associated protein Tau. This reduces the affinity of Tau to bind microtubules and increases the levels of soluble detached Tau in neurons. Previous ERC-supported work from my lab...