Periodic Reporting for period 4 - DCRIDDLE (A novel physiological role for IRE1 and RIDD..., maintaining the balance between tolerance and immunity?)

Dendritic cells (DCs) play a crucial role as gatekeepers of the immune system, coordinating the balance between protective immunity and tolerance to self-antigens. They enter peripheral tissues as immature (resting) DCs, looking for antigens to grab. Once they’ve acquired an...