Pressure and curvature control of the cell cycle in epithelia growing under spherical confinement

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Authors: Morphogenesis requires spatiotemporal regulation of proliferation, both by biochemical and mechanical cues. In epithelia, this regulation is called contact inhibition of proliferation, but disentangling biochemical from mechanical cues remains challenging. Here, we show that epithelia growing under confinement accumulate pressure that inhibits proliferation above a threshold value. During growth,

Journal title: Cell Reports

Journal publisher: Cell Press

Published year: 2022

DOI identifier: 10.1016/j.celrep.2022.111227

ISSN: 2211-1247