Periodic Reporting for period 4 - SelectiveTGFb-inhib (Pro-tumorigenic effects of TGFb - elucidation of mechanisms and development of selective inhibitors)

What is the problem/issue being addressed?The multifunctional cytokine transforming growth factor-beta (TGFbeta) has important functions during the embryonal development and in tissue homeostasis. In cancer, TGFbeta has been found to have tumor suppressive activities at early...