Periodic Reporting for period 3 - RetroChrom (Deciphering the molecular mechanisms of HIV DNA nuclear import and the impact of 3D genome organization on integration site selection)

Chromosomes of eukaryotes adopt highly dynamic and complex hierarchical structures in the nucleus. The three-dimensional (3D) organization of chromosomes profoundly affects DNA functions, primarily transcription. During retroviral infection, histone-free viral DNA copy is...