Periodic Reporting for period 3 - BASILIC (Decoding at systems-level the crosstalk between the T cell antigen receptor, the CD28 costimulator and the PD-1 coinhibitor under physiological and pathological conditions.)

Although the T cell antigen receptor (TCR) occupies a central place in the activation of T lymphocytes, it does not work in isolation and the key activation signals it triggers are tuned by several other receptors expressed at the T cell surface that deliver positive...