Periodic Reporting for period 1 - AvINFLUENZA (Molecular basis of avian influenza polymerase adaptation to human hosts)

Influenza A virus (IAV) is responsible for 3–5 million severe cases every year, resulting in 250 000-500,000 deaths. Most influenza strains evolve exclusively in water birds, but some highly pathogenic avian strains (e.g., H5N1, H5N8 and H7N9) can infect humans with lethal...