Periodic Reporting for period 1 - Targeting TopoII (Mechanistic studies of metal-dependent DNA cleavage in Type II topoisomerase toward therational design of novel anticancer drugs)

Type II topoisomerase (TopoII) metalloenzymes play a crucial role in regulating DNA topology in replication, transcription, recombination, and repair processes. TopoII is thus a validated target for clinical antibiotics and anticancer drugs, such as etoposide (ETO). ETO is an...