Periodic Reporting for period 2 - PARPinhibit (A systems biology approach to tackle PARP-inhibitors resistance and identify novel therapeutic targets to overcome it)

The Poly(ADP-ribose) polymerase 1 (PARP1) gene encodes a nuclear protein that transfers ADP-ribose residues (PAR) onto target substrates; this post-translational modification is called PARylation. Inhibition of PARP1 is widely used in cancer therapy to treat cancers where DNA...