Periodic Reporting for period 1 - TET2rec (Mechanisms of TET2 DNA demethylase recruitment to specific genomic regions)

Acute myeloid leukemia (AML) patients frequently harbor mutations in the epigenetic modifier TET2, which is a DNA demethylase. DNA methylation is an epigenetic modification that occurs predominantly at CpG dinucleotides and have a major impact on transcription. Accordingly, it...