Periodic Reporting for period 1 - RecInRep (Beyond double-strand break repair: specific mechanisms of homologous recombination at stressed replication forks.)

About 10 years ago, breakthrough studies established oncogene-induced replication stress as an early, driving event in tumourigenesis. Deregulated DNA replication fuels genomic instability, driving precancerous lesions into full cellular transformation by inactivation of key...