Periodic Reporting for period 1 - DUALgRENP (A DUAL gRNA system for functional assessment of ENhancers in Pluripotency)

Enhancers are cis-regulatory genomic regions that can modulate gene expression in a cell type-specific and time-controlled manner to regulate cellular behavior. ChIPseq, 4C-seq, RNA-seq and reporter assays have allowed the genome-wide identification of potential enhancers...