Optimized nanoparticle formulations for topical delivery

This deliverable will be achieved through: Task 4.1 production and in vitro performance testing of a range of nanoparticle delivery systems (containing vitamin A) Task 4.2 (to UoN) Characterisation of the resulting nanoparticulate formulations by AFM, ToF-SIMS, SEM and other analysis techniques Task 4.3 Franz cell (ex vivo) and skin model (in vivo) testing of the developed formulations (to investigate permeation, potential safety issues etc) Task 4.4 Physicochemical analysis of samples from ex vivo and in vivo permeation studies to determine permeation properties, such as depth and localisation.