An optimized, tunable nanoparticle platform formulation for oral delivery applications

This deliverable will be acheived through: Task 3.1 & Task 3.3 - The production, in-vitro characterization (size, morphology, drug loading efficiency) and optimization of nanoparticles loaded with drugs of different solubility and permeability properties (e.g. selected from the 4 classes of the Biopharmaceutical Classification System (BCS) for poorly soluble model drugs). Test formulations for model biopharmaceuticals (e.g. insulin) will also be prepared and characterized. Task 3.2 & Task 3.4 - in-vitro drug release studies and in-house cell models to study intestinal adsorption.