Periodic Reporting for period 1 - MetabolACE (Histone modifying enzymes as direct regulators of metabolic reprogramming: Towards a New Paradigm)

Epigenetic regulation relies on the activity of enzymes that use sentinel metabolites as cofactors to modify DNA or histone proteins. Thus, fluctuations in cellular metabolite levels have been reported to affect chromatin modifications. However, whether epigenetic modifiers...