Periodic Reporting for period 1 - RNA-SHAPE (Structure and function of repeat-derived non-coding RNAs in epigenetic regulation of mammalian pericentric heterochromatin)

A significant fraction of mammalian genomes is composed of repetitive elements, such as pericentric major satellite repeats. Repetitive elements present a critical challenge to genome stability because these regions are prone to recombination. To safeguard genome integrity...