Periodic Reporting for period 1 - TargetDUBs (Targeting ubiquitin processing in cancer and fibrosis: novel probes for the Ubiquitin Carboxy-Terminal Hydrolases)

Ubiquitin specific peptidase 30 (USP30) is a member of the USP family of deubiquitinases (DUBs) and the only DUB present in mitochondria, where it deubiquitylates mitochondrial proteins and antagonizesmitophagy. USP30 overexpression is strongly associated with drug resistant...