Periodic Reporting for period 1 - MiniBRAIN (Investigating the pathogenic mechanisms underlying TUBB2B-related brain malformations using induced pluripotent stem cells and cerebral organoids.)

Tubulin proteins (encoded by a family of highly-conserved tubulin genes) play important structural and mechanical roles within cells, including those involved in embryonic brain development. In recent years, mutations affecting a family of tubulin genes expressed highly during...