Periodic Reporting for period 1 - TCELLTIGIT (Structural characterization of immune signaling protein TIGIT using x-ray crystallography and cryo-electron microscopy)

Immunosignaling proteins are the target of anti-cancer and anti-viral immunotherapies. These proteins are known as single pass transmembrane receptors and consist of 3 parts: an extracellular domain (ECD), a transmembrane (TM) domain, and an intracellular domain (ICD). The TM...