Periodic Reporting for period 1 - MECHANOCHECK (ATR-mediated mechanotransduction and connections with the actin cytoskeleton)

ATR is a protein kinase that controls DNA damage response (DDR), together with ATM, Chk1 and Chk2. DDR genes are often mutated in cancer cells and act as an anti-cancer barrier in response to oncogenic stimuli. ATR is essential and protects the integrity of replicating...