Periodic Reporting for period 1 - EMCOP9CRL (Structural basis of Cullin-RING ligase regulation by the COP9 signalosome)

The components of the Cullin-RING Ligase (CRLs) E3 ubiquitin ligase family play key roles in a wide range ofcellular processes including stress response, signal transduction, apoptosis and cell cycle progression, andaccordingly, defects in their function and/or regulation are...