Personnalized 11C PET aided hadron therapy

Personalized 11Carbon PET aided hadron therapy Objective: to adapt the treatment plan according to PET response halfway through the course of hadron therapy, to investigate hypoxia tracers, fluorinated aminoacides or DNA synthesis markers and to validate PET for early response assessment. Expected Results: select most suitable PET tracers for adaptive hadron therapy and early response evaluation. New tracers will be investigated including hypoxia tracer (a non exhaustive list is: 18F-MISO, 18F-FAZA, 62Cu-ATSM) other fluorinated aminoacids (18F-FET, 18F-FACBC, etc.) or DNA synthesis markers (18- fluorothymidine). The tools developed for FLUKA will be verified at CNAO in a clinical scenario. Comparisons with the standard 12C treatment plans will be studied in terms of dose, biological effect and ß+-emitters distributions